Collection of erythropoietin from urine of patients with anemia secondary to hookworm.

More abundant and less costly sources of erythropoietic hormone are needed.’ Erythropoietin can be concentrated from the plasma or urine of acutely hypoxic or severely anemic animals or human the least expensive source is urine of severely anemic Very high concentrations of erythropoietin are found in the urine of some patients with severe hypoplastic anemia, hemolytic anemia, blood loss anemia or anemia secondary to leukemia. However, the urine of many such patients must be assayed in order to find that urine which has a sufficiently high concentration of erythropoietin to be valuable as a source, and the urines with the highest concentrations are often from patients who are terminal and therefore only temporary sources and very few in numbers. This study of the erythropoietin extract of a large number of patients with severe anemia secondary to hookworm was undertaken in an attempt to find a more reliable and inexpensive source of human urinary erythropoietin.